منابع مشابه
mTOR pathway: A current, up-to-date mini-review (Review)
Mammalian target of rapamycin (mTOR) is a protein serine/threonine kinase that was initially identified as the cellular target of rapamycin. This kinase regulates cell growth, proliferation, motility and survival, as well as the gene transcription and protein synthesis that are activated in response to hormones, growth factors and nutrients. Results from preclinical studies have indicated that ...
متن کاملTargeting the mTOR kinase domain: the second generation of mTOR inhibitors.
The mTOR signaling pathway is dysregulated in ∼50% of all human malignancies and is a major cancer drug target. Although rapamycin analogs (rapalogs) have shown clinical efficacy in a subset of cancers, they do not fully exploit the antitumor potential of mTOR targeting. Because the mTOR kinase domain is important for rapamycin-sensitive and -insensitive functions, mTOR catalytic inhibitors hav...
متن کاملmTOR inhibitors in sarcoma.
GD Over the last decade, pathology and diagnostics have assumed a new importance in sarcoma. In the past, the belief was that all sarcomas were alike: some were bone sarcomas and some were soft-tissue sarcomas, but it did not matter because the only treatment available if surgery and radiotherapy failed was chemotherapy, and this was only rarely directed at specific subtypes of sarcomas. Some s...
متن کاملNanomolar mTOR Inhibitors
7 ABSTRACT: The mammalian target of rapamycin (mTOR) 8 has an important role in cell growth, proliferation, and survival. 9 mTOR is frequently hyperactivated in cancer, and therefore, it 10 is a clinically validated target for cancer therapy. In this study, 11 we combined exhaustive pharmacophore modeling and 12 quantitative structure−activity relationship (QSAR) analysis 13 to explore the stru...
متن کاملTargeting glutaminase and mTOR
Comprehensive genomic and proteomic analyses demonstrate that there is nearly universal activation of the PI3K pathway in glioblastoma (GBM) patients [1]. Persistent PI3K signaling promotes GBM formation and tumor progression in genetic mouse models, establishing PI3K and its effecter mTOR as compelling molecular targets. mTOR, which has two distinct complexes, mTORC1 and mTORC2, is a protein k...
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ژورنال
عنوان ژورنال: Biorganic and Medicinal Chemistry Reports
سال: 2019
ISSN: 2667-6028
DOI: 10.25135/bmcr.16.19.09.1417